Chemical Research

Agnitio Pharma is a leading chemical company that has a top-line chemistry services platform for the custom synthesis of efficient, economic, high-quality complex organic molecules for Biotech and Pharmaceutical applications. In the mg to Kg scale, from idea to final product is a key capability.

We believe in complete transparency and follow the policy of “No Solutions No Pay”. We like to meet challenges and demonstrate our skills in our catalogue products. 

Chemistry at Agnitio 

• Alkylation
• Amination
• Anhydrous Anaerobic Reaction
• Cyanation
• Diazotization
• Esterification
• Friedel-Crafts Reaction
• Grignard’s Reaction
• Halogenation Reaction
• Hydrogenation (Pd /C, Pt)
• Lithiation
• Nitration
• Oxidation
• Reduction (NaBH4, Fe)
• Suzuki Coupling Reaction
• Mitsunobu Reaction 
• Asymmetric Synthesis 
• Kinetic/chemical Resolution

We, at Agnitio, believe in transforming seeds to plant and thus provide expertise in translating smaller Research Batches into commercial production. Our chemical engineers and process chemist works cohesively to simulate the R&D Process into a plant-friendly process. 

Simulation Process involves 

• Reaction Calorimetry 
• Identification of Critical Process Parameter
• Identification of Design Space and Operational Range 
• Process Impurity Profiling from KSM to Final Product 
• Green Chemistry Principle
• PMI

Design or Selection of Route of Synthesis (RoS) of molecules is an art to convert ideas to the molecule. Retro-Synthesis, selection of less expensive, commercially available synthon, Reagents & Solvents, and process operability is the modern key for the selection of RoS. Drivers such as Safety, Environmental, Legal, Economic, Control & Throughput knows a “SELECT” also governs the selection of RoS.   

We believe in the “Right First Time” and pay close attention to every chemical transformation involved in the RoS.  To meet the RFT goals, Agnitio Questioned himself for 

• Chemical Yields
• Cycle Time 
• Number of Chemical Steps and Convergence
• Use of higher molecular weight protecting groups and reagents 
• Number of energy-consuming operations 

We create the Technology Transfer Documents (TTD) which helps to transfer technology from R&D to commercialization. TTD covers all basic areas in chemical process engineering: design, operation, analysis, optimization, troubleshooting, control, safety, and supervision of chemical processing operations. 

Agnitio TTD includes 

Product Details, KSM Details, Raw Material, Intermediates, Stage of Synthesis, Reprocessing, Process Flow Chart, Process Parameters, In-process Controls, Design of Experiments (DoE) & Quality by Design, Critical Process Parameters, Solubility of raw materials intermediate & API, Isomerism, Polymorphism, Process Validation Report, Holding Time Data of Intermediates, and stability of the finished product, Storage & Packaging, Safety & Environment, and Material Safety Data Sheet.